Galactosyltransferase Inhibitors

Abstrakt

Oligosaccharides in glycoconjugates form a sugar code in cell-cell recognition processes. Since galactosyltransferases are responsible for the biosynthesis of galactose-containing oligosaccharides, inhibitors of these enzymes are targets for drug design. In this review, the current state of the development of galactosyltransferase inhibitors, based on the donor and transition-state structures and bisubstrate analogues, is summarised.