I. Jambal
Department of Chemistry of Natural Compounds, Institute of Chemical Technology, Prague
K. Kefurt
Department of Chemistry of Natural Compounds, Institute of Chemical Technology, Prague
J. Moravcová
Department of Chemistry of Natural Compounds, Institute of Chemical Technology, Prague
Abstrakt
Oligosaccharides in glycoconjugates form a sugar code in cell-cell recognition processes. Since galactosyltransferases are responsible for the biosynthesis of galactose-containing oligosaccharides, inhibitors of these enzymes are targets for drug design. In this review, the current state of the development of galactosyltransferase inhibitors, based on the donor and transition-state structures and bisubstrate analogues, is summarised.
