Galactosyltransferase Inhibitors

  • I. Jambal Department of Chemistry of Natural Compounds, Institute of Chemical Technology, Prague
  • K. Kefurt Department of Chemistry of Natural Compounds, Institute of Chemical Technology, Prague
  • J. Moravcová Department of Chemistry of Natural Compounds, Institute of Chemical Technology, Prague

Abstrakt

Oligosaccharides in glycoconjugates form a sugar code in cell-cell recognition processes. Since galactosyltransferases are responsible for the biosynthesis of galactose-containing oligosaccharides, inhibitors of these enzymes are targets for drug design. In this review, the current state of the development of galactosyltransferase inhibitors, based on the donor and transition-state structures and bisubstrate analogues, is summarised.
Publikované
2012-05-15
Sekce
Články