Voltampérometrické stanovenie antidepresíva imipramínu vo farmaceutických prípravkoch pomocou bórom dopovanej diamantovej elektródy

Abstrakt

Herein, the direct electroanalytical determination of antidepressant imipramine using a boron-doped diamond electrode is presented. Cyclic and linear sweep voltammetric measurements revealed one distinct, irreversible and diffusion-controlled oxidation peak at +0.75 V (vs. Ag/AgCl) and oval-shaped peaks at +1.0 V and +1.5 V in the presence of Britton-Robinson buffer at pH 9. Using differential pulse voltammetry, the peak current of IMIP was found to be linear function of the concentration from 1.5 to 19.4 µM with the obtained detection limit of 0.5 µM and good repeatability (relative standard deviation of 5.4 % for n = 20 at 1.5 µM IMIP). The practical usefulness of the developed method was successfully manifested on the analysis of pharmaceutical tablets with significant recoveries (99.0–100.4 %). Finally, boron-doped diamond electrode could be considered as an alternative to widely used chemically modified electrodes in antidepressant sensing and may be applied as a sensitive electrochemical sensor in routine pharmaceutical analysis.