Targeting of Drugs into Colon

Authors

  • K. Dvořáčková Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno
  • A. Franc Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno
  • M. Kejdušová Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno

Keywords:

site specific drug delivery, colon, drug systems

Abstract

In recent years, drug delivery into colon has gained importance in treatment of colon diseases and systemic absorption of peptide drugs. This review is focused on parameters of the gastrointestinal tract influencing the drug and delivery systems as well as on the main pharmaceutical approaches to colon delivery. The review describes the use of pH-sensitive polymers, polymers biodegradable by colon microflora, azo polymers and other methods resul­ting in pH-, microbially-, pressure- and time-controlled colon-specific drug delivery systems. The review also covers electronic devices for the purpose. Colon drug delivery offers various therapeutic benefits for patients especially in treatment of local diseases. Its use for systemic drug absorption remains a challenge for future.

Published

2013-07-15

How to Cite

Dvořáčková, K., Franc, A., & Kejdušová, M. (2013). Targeting of Drugs into Colon. Chemické Listy, 107(7), 522–529. Retrieved from http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/645

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