The Use of Texture Analysis in Development and Evaluation of Matrix Tablets with Prolonged Drug Release

Authors

  • D. Pěček Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno
  • M. Štýbnarová Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno
  • E. Mašková Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno
  • P. Doležel Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno
  • M. Kejdušová Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno
  • D. Vetchý Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno
  • K. Dvořáčková Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno

Keywords:

texture analysis, gel layer thickness, matrix tablets, dissolution profile, statistical processing

Abstract

Texture analysis as a versatile tool for testing the inner structure of materials has been widely used. Though being also used in pharmaceutical industry, it has not been included in standard procedures for evaluation of drug dosage forms. The aim of this study is to measure the thickness of gel layer using texture analysis for the prediction of dissolution profile of very soluble drugs based on hydrophilic and hydrophilic-lipophilic matrix tablets. For the evaluation of the correlation between the thickness of the gel layer as an independent variable and the amount of a released drug as a dependent variable at given time intervals, the multivariate method of partial least squares – PLS-2 regression was used. For the prediction of dissolution characteristics of matrix tablets, a PLS-2 model validated by full cross-validation was developed. A PLS-2 model validated by full cross-validation was developed.

Published

2014-05-15

How to Cite

Pěček, D., Štýbnarová, M., Mašková, E., Doležel, P., Kejdušová, M., Vetchý, D., & Dvořáčková, K. (2014). The Use of Texture Analysis in Development and Evaluation of Matrix Tablets with Prolonged Drug Release. Chemické Listy, 108(5), 483–487. Retrieved from http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/507

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