IGF2: Overlooked Peptide from Insulin-Like Family of Hormones with Great Therapeutical Potential

The article is dedicated to the 70ᵗʰ anniversary of the founding of the Institute of Organic Chemistry and Biochemistry of the CAS in Prague

Authors

  • Tereza Turnovská Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic
  • Jiří Jiráček Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic https://orcid.org/0000-0003-3848-2773
  • Lenka Žáková Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic https://orcid.org/0000-0001-6439-2574

DOI:

https://doi.org/10.54779/chl20240321

Keywords:

IGF2, insulin, insulin receptor, IGF2 receptor, carcinogenesis, neurodegenerative diseases, embryogenesis

Abstract

Insulin-like growth factor 2 (IGF2), along with several other insulin-like peptides, belongs to an evolutionarily conserved family of signalling molecules essential for normal cell proliferation and brain development. Previous studies have mainly focused on its role in embryonic development and carcinogenesis. In recent years, new insights revealed the role of IGF2 in the central nervous system, particularly its importance in learning, memory consolidation and enhancement. Despite the still not fully explored physiological role of IGF2, in this article we aim to describe and explain its known functions in more detail and discuss its potential uses, including its possible application in the treatment of neurodegenerative diseases.

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Published

2024-06-15

How to Cite

Turnovská, T., Jiráček, J., & Žáková, L. (2024). IGF2: Overlooked Peptide from Insulin-Like Family of Hormones with Great Therapeutical Potential: The article is dedicated to the 70ᵗʰ anniversary of the founding of the Institute of Organic Chemistry and Biochemistry of the CAS in Prague. Chemické Listy, 118(6), 321–330. https://doi.org/10.54779/chl20240321

Issue

Vol. 118 No. 6 (2024)

Section

Articles