Effect of Electrostatic Charge on the Production and Composition of Pharmaceuticals

Authors

  • L. Gruberová Department of Solid State Chemistry, Institute of Chemical Technology, Prague
  • B. Kratochvíl Department of Solid State Chemistry, Institute of Chemical Technology, Prague
  • A. Jegorov Teva Czech Industries, České Budějovice

Keywords:

electrostatic charge, contact charging, bulk pharmaceutical substances, solid dosage form

Abstract

Powdery pharmaceuticals are prone to electrostatic charging due to collisions of particles and friction with device walls. The generated electrostatic charge is influenced by particle properties, processing and conditions. The charge of active particles and excipients is often inconvenient being able to cause problems in the production of solid dosage forms. The electrostatic charge of powdery particles affects properties of the materials and all procedures as the charge affects the behaviour and purity of the final dosage form. The problem of electrostatic charging of powders is more complicated when two or more compounds with different physical, chemical and dielectric properties are combined. To better understand the mechanism of electrostatic charging it is necessary to explain all the effects that contribute to charging solid active ingredients and excipients.

Published

2014-09-15

How to Cite

Gruberová, L., Kratochvíl, B., & Jegorov, A. (2014). Effect of Electrostatic Charge on the Production and Composition of Pharmaceuticals. Chemické Listy, 108(9), 853–858. Retrieved from http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/465

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