Development and Application of Bioorthogonal Reactions for Drug Imaging and Activation

The article is dedicated to the 70ᵗʰ anniversary of the founding of the Institute of Organic Chemistry and Biochemistry of the CAS in Prague

Authors

  • Milan Vrábel Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic https://orcid.org/0000-0001-6633-4351
  • Veronika Šlachtová Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic https://orcid.org/0000-0001-8560-3916

DOI:

https://doi.org/10.54779/chl20240130

Keywords:

click chemistry, bioorthogonal reactions, imaging, fluorescent labeling, prodrugs

Abstract

Chemical transformations compatible with biological systems serve as invaluable tools for probing biomolecules, drug compounds, and biological processes in their native environments. The complex environment of living organisms requires these reactions to be highly selective and efficient, posing a formidable challenge to the field of organic chemistry. A number of chemical reactions have recently emerged to meet this challenge, providing a diverse toolkit for researchers. This manuscript presents a comprehensive survey of current bioorthogonal reactions, emphasizing their applications in bioimaging, diagnostics, and medicine.

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Published

2024-03-15

How to Cite

Vrábel, M., & Šlachtová, V. (2024). Development and Application of Bioorthogonal Reactions for Drug Imaging and Activation: The article is dedicated to the 70ᵗʰ anniversary of the founding of the Institute of Organic Chemistry and Biochemistry of the CAS in Prague. Chemické Listy, 118(3), 130–137. https://doi.org/10.54779/chl20240130

Issue

Vol. 118 No. 3 (2024)

Section

Articles