Oncogenic Forms of Isocitrate Dehydrogenase: Mechanisms of Carcinogenesis and Development of Resistance to Chemotherapeutics

Authors

  • Veronika Vozáriková Department of Genetics, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia https://orcid.org/0000-0003-0852-9032

DOI:

https://doi.org/10.54779/chl20220536

Keywords:

isocitrate dehydrogenase, oncogenic mutation, ᴅ-2-hydroxy glutarate, chemotherapy, resistance

Abstract

Many types of tumors harbor a mutation in the gene for the metabolic enzyme isocitrate dehydrogenase resulting in the production of the oncometabolite ᴅ-2-hydroxy glutarate with a pleiotropic effect on the cell. The paper provides an overview of the latest knowledge of the me­chanism of carcinogenesis, of specific drugs suppressing ᴅ-2-hydroxy glutarate production and of the causes of resistance complicating treatment based on specific inhibitors of oncogenic forms of isocitate dehydrogenase.

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Published

2022-09-15

How to Cite

Vozáriková, V. (2022). Oncogenic Forms of Isocitrate Dehydrogenase: Mechanisms of Carcinogenesis and Development of Resistance to Chemotherapeutics. Chemické Listy, 116(9), 536–542. https://doi.org/10.54779/chl20220536

Issue

Vol. 116 No. 9 (2022)

Section

Articles