The Effects of Lactic Acid in Tumor Microenvironment

Authors

  • M. Koncošová Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Prague http://orcid.org/0000-0002-8951-1282
  • T. Ruml Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Prague
  • J. Zelenka Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Prague http://orcid.org/0000-0001-8145-8037

Keywords:

lactate, lactic acid, acidosis, tumor microenvironment, therapy

Abstract

Malignant transformation of the cells leads to a change in their metabolism, characterized mainly by increased glucose uptake and its conversion to lactic acid, which has a significant signaling role in the tumor microenvironment. Lactic acid is important for energy cell metabolism: it has an immunosuppressive role, can promote angiogenesis, repair mechanisms, invasiveness, and metastasis. The study of therapeutic opportunities of targeting lactic acid metabolism currently represents an outstandingly exposed field of research that could contribute to improving the prognosis of cancer patients.

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Published

2020-05-15

How to Cite

Koncošová, M., Ruml, T., & Zelenka, J. (2020). The Effects of Lactic Acid in Tumor Microenvironment. Chemické Listy, 114(5), 336–340. Retrieved from http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3601

Issue

Vol. 114 No. 5 (2020)

Section

Articles