Prolyl Oligopeptidase in Physiology and Pathology

Authors

  • P. Fajtová Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague
  • M. Horn Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague

Keywords:

proteolytic enzymes, serine peptidase, prolyl oligopeptidase, physiological role

Abstract

Prolyl oligopeptidase is an atypical serine peptidase which digests bioactive peptides, including hormones and neuropeptides. Prolyl oligopeptidase cleaves internal peptide bonds on the C-terminal side of proline residues. Orthologous enzymes are found in plants, bacteria, fungi, protozoa, invertebrates and vertebrates. This review provides an update on function and structure of prolyl oligopeptidase; it is also focused on its biological role and implication in physiological processes and disorders.

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Published

2019-12-15

How to Cite

Fajtová, P., & Horn, M. (2019). Prolyl Oligopeptidase in Physiology and Pathology. Chemické Listy, 113(12), 732–737. Retrieved from http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3505

Issue

Vol. 113 No. 12 (2019)

Section

Articles