Determination of Antiarrhythmics and Their Metabolites in Clinical Samples Using a SPE-HPLC Combination

Authors

  • E. Brandsteterova Department of Analytical Chemistry, Faculty of Chemical Technology, Slovak Technical University, Bratislava, Slovak Republic
  • A. Ferencova Department of Analytical Chemistry, Faculty of Chemical Technology, Slovak Technical University, Bratislava, Slovak Republic

Abstract

An effective and simple SPE-HPLC assay for monitoring of clinically applied antiarrhythmics and their metabolites in serum samples was developed. In particular, the generally used SPE step has been modified for the clean-up and preconcentration procedure of clinical samples. Extraction recoveries for all analyzed compounds were in the range 81.4-90.7% for the concentration level m g.ml-1 of serum.

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Published

1999-05-15

How to Cite

Brandsteterova, E., & Ferencova, A. (1999). Determination of Antiarrhythmics and Their Metabolites in Clinical Samples Using a SPE-HPLC Combination. Chemické Listy, 93(4). Retrieved from http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/2627

Issue

Vol. 93 No. 4 (1999)

Section

Articles