Fibrin Formation and Degradation
Abstract
Fibrinogen conversion to fibrin is a physiological process leading to haemostasis. Fibrinogen is cleaved by the serine protease thrombin to the fibrin monomer, which interacts with other fibrin monomers to produce protofibrils, which in turn spontaneously interact to form fibres. Fibrin formation activates specific proteases, which cleave plasminogen to plasmin. Plasmin degrades the fibrin network and disintegrates the haemostatic plug. The processes are regulated and are not yet fully clarified. This review brings an insight into these physiological processes.Downloads
Published
2008-06-15
How to Cite
Kotlín, R., & Dyr, J. E. (2008). Fibrin Formation and Degradation. Chemické Listy, 102(5). Retrieved from http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/1648
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