Increasing Bioavailability of Poorly Water-Soluble Drugs by Technological Methods Facilitating Drug Dissolution

Authors

  • Ladislava Okáčová Department of Pharmaceutics, Faculty of Pharmacy, Veterinary and Pharmaceutical University, Brno
  • David Vetchý Department of Pharmaceutics, Faculty of Pharmacy, Veterinary and Pharmaceutical University, Brno
  • Aleš Franc Department of Pharmaceutics, Faculty of Pharmacy, Veterinary and Pharmaceutical University, Brno
  • Miloslava Rabišková Department of Pharmaceutics, Faculty of Pharmacy, Veterinary and Pharmaceutical University, Brno

Keywords:

sparingly soluble drugs, increasing drug solubility, increasing bioavailability, tensides, cosolvents, cyclodextrins, chelation, pH modifiers, solid dispersions, interactive powder mixtures, microgranulation, aggregation granulation, impregnation, particle reduction

Abstract

The paper brings an overview of most important methods for attaining the purpose, such as solubilization using tensides, cosolvents, chelates, cyclodextrins, pH modifiers, interactive powder mixtures forming solid dispersions and microgranulates. The review summarizes main advantages and drawbacks of the methods and gives some examples. Although, the most frequently used technology in pharmaceutical industry is currently drug micronization, the above methods offer a well established way of enhancing solubility of drugs in water.

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Published

2011-01-15

How to Cite

Okáčová, L., Vetchý, D., Franc, A., & Rabišková, M. (2011). Increasing Bioavailability of Poorly Water-Soluble Drugs by Technological Methods Facilitating Drug Dissolution. Chemické Listy, 105(1), 34–40. Retrieved from http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/1193

Issue

Vol. 105 No. 1 (2011)

Section

Articles