Imunochemická analýza von Willebrandova faktoru a její klinické využití

  • F. Mareček Laboratoř pro poruchy hemostázy, Ústav hematologie a krevní transfuse, Praha
  • I. Hrachovinová Laboratoř pro poruchy hemostázy, Ústav hematologie a krevní transfuse, Praha
Klíčová slova: poruchy hemostázy, von Willebrandova choroba, von Willebrandův faktor, hemofilie A

Abstrakt

The aim of the present work is the laboratory confirmation (or exclusion) of the von Willebrand disease (VWD) diagnosis in patients with a suspect bleeding disorder and determination of the disease type. We used electrophoretic separation followed by an immunochemical chemiluminescent detection of the von Willebrand factor multimers. In the tested sample of 260 patients (in 2000–2010), all the three primary categories of the VWD were detected. The VWD categories were of type 1 (71 %), of type 2A/B/E (24.7 %) and of type 3 (3.6 %). Our findings in the Czech population are close to the data of other research groups.

Publikované
2013-05-15
Sekce
Články