Vplyv technologických vlastností suchého extraktu na vlastnosti tabliet

  • T. Haršányová Katedra galenickej farmácie, Farmaceutická fakulta, Univerzita Komenského, Bratislava, Slovensko
  • T. Wolaschka Katedra farmaceutickej technológie, Univerzita veterinárskeho lekárstva a farmácie v Košiciach, Košice, Slovensko
  • D. Matušová Katedra galenickej farmácie, Farmaceutická fakulta, Univerzita Komenského, Bratislava, Slovensko
  • K. Bauerová Katedra galenickej farmácie, Farmaceutická fakulta, Univerzita Komenského, Bratislava, Slovensko ǀ Centrum experimentálnej medicíny Slovenskej akadémie vied, Ústav experimentálnej farmakológie a toxikológie, Bratislava, Slovensko
Klíčová slova: extrakt, rozchodnica ružová, perorálne tablety, sorbitol, mikrokryštalická celulóza, disolúcia

Abstrakt

Salidroside, as a chemical compound from the group of phenylpropanoids, and rosavin are used for the standardization of dry extracts from the underground stem and root of Rhodiola rosea. In this study we monitored two different extracts from Rhodiola rosea, which differ in content of active compounds, colour, technological and physico-chemical properties (e.g. flow properties). These extracts were mixed with excipients and the flow characteristics of mixture – bulk volume and tapped volume – were determined. After formulating the tablets by compression, qualitative parameters like disintegration, resistance to crushing, friability, mass uniformity and texturometric parameters were tested. Also, dissolution profiles were evaluated using first order kinetic model, Korsmeyer-Peppas model and Weibull model for correlation. In some formulations, the impact of the properties of dry extracts on various technological properties of final tablets was more marked. We suggest that in case of a higher extract:excipients ratio, these properties manifest themselves by an even higher impact.

Publikované
2020-12-15
Sekce
Články

Nejaktuálnější články stejného autora (stejných autorů)