Protinádorové a anti-HIV deriváty betulinové kyseliny [Anticancer and Anti-HIV Derivatives of Betulinic Acid]
Klíčová slova:kyselina betulinová, anti-HIV-1, anti-HIV-2, protinádorová aktivita
Betulinic acid and its derivatives modifying its physicochemical and biological properties contain a promising pharmacophore, which, so far only experimentally, are used as a structural basis for substances that function as antitumor and anti-HIV-1 and -2 agents. An overview of derivatives, classified according both structural characteristics and the type of the effect, is given. Although betulinic acid has been extensively studied since the 1990s, it has not yet been possible to prepare any sufficiently effective and safe derivative useful in clinical practice that could be marketed as a registered drug.
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