Prolyloligopeptidasa ve fyziologii a patologii

  • P. Fajtová Ústav organické chemie a biochemie, Akademie věd České republiky, Praha
  • M. Horn Ústav organické chemie a biochemie, Akademie věd České republiky, Praha
Klíčová slova: proteolytické enzymy, serinová peptidasa, prolyloligopeptidasa, fyziologická role

Abstrakt

Prolyl oligopeptidase is an atypical serine peptidase which digests bioactive peptides, including hormones and neuropeptides. Prolyl oligopeptidase cleaves internal peptide bonds on the C-terminal side of proline residues. Orthologous enzymes are found in plants, bacteria, fungi, protozoa, invertebrates and vertebrates. This review provides an update on function and structure of prolyl oligopeptidase; it is also focused on its biological role and implication in physiological processes and disorders.

Publikované
2019-12-15
Sekce
Články