Study of Stability of 4-Aminophenol as Dominant Decomposition Product of Paracetamol

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  • L. Hanysova Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Hradec Kralove
  • P. Kastner Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Hradec Kralove
  • J. Klimes Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Hradec Kralove

Abstrakt

An HPLC method for determination of very low concentrations of 4-aminophenol was elaborated, and the kinetics of its decomposition at low temperatures and at laboratory temperature in the absence of light or under irradiation at 254 nm were compared. To increase the sensitivity of the method, derivatization of 4-aminophenol with various reagents was tested. Phthalaldehyde proved to be the best; its reaction at laboratory temperature in the presence of 2-sulfanylethanol is very fast. The derivatization conditions were optimized.

Stahování

Publikováno

15.04.2004

Jak citovat

Hanysova, L., Kastner, P., & Klimes, J. (2004). Study of Stability of 4-Aminophenol as Dominant Decomposition Product of Paracetamol. Chemické Listy, 98(3). Získáno z http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/2156

Číslo

Vol 98 No 3 (2004)

Sekce

Články