Extrakty ako moderná lieková forma pre prírodné liečivá

Autoři

  • S. Kurhajec Katedra farmakognózie a botaniky, Univerzita veterinárneho lekárstva a farmácie v Košiciach, Košice, Slovensko | Ústav technologie léků, Farmaceutická fakulta, Veterinární a farmaceutická univerzita Brno, Brno, Česká republika
  • D. Sabadková Ústav technologie léků, Farmaceutická fakulta, Veterinární a farmaceutická univerzita Brno, Brno, Česká republika
  • A. Franc Ústav technologie léků, Farmaceutická fakulta, Veterinární a farmaceutická univerzita Brno, Brno, Česká republika
  • D. Vetchý Ústav technologie léků, Farmaceutická fakulta, Veterinární a farmaceutická univerzita Brno, Brno, Česká republika

Klíčová slova:

rastlinné extrakty, extrakčné metódy, prírodné látky

Abstrakt

Plant extracts still constitute a part of commonly used dosage forms, but they can also be understood as raw materials for pharmaceutical industry. The production of extracts is based on the periodic, continuous and semi-continuous methods, which can also be classified as conventional extraction methods (maceration, percolation, infusion, decoction, distillation, Soxhlet extraction, ultrasound assisted extraction and headspace extraction) or modern extraction methods (supercritical fluid extraction, pressurized liquid extraction, microwave assisted extraction, solid phase micro extraction, stir bar sorptive extraction, matrix solid phase dispersion, quick easy cheap rugged effective and safe extraction). The extraction-method efficiency depends on the characteristics of the extracted material (e.g. particle size, ballast materials, thickness of the cell wall), physical factors (e.g. temperature, pressure, microwave, ultrasound), the extraction time, mixing (it influences the concentration gradient), solvent type and the presence of cosolvent. For environmental reasons, it is suitable to produce the extracts by using certain gases in supercritical conditions as solvents (e.g. carbon dioxide, nitrogen) or other generally recognized as safe solvents (e.g. water, propylene glycol) that provide a high yield at a correct methodology.

Stahování

Publikováno

15.04.2017

Jak citovat

Kurhajec, S., Sabadková, D., Franc, A., & Vetchý, D. (2017). Extrakty ako moderná lieková forma pre prírodné liečivá. Chemické Listy, 111(4), 251–257. Získáno z http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/89

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