Ultravysokomolekulární polyethylen pro kloubní náhrady se zvýšenou životností

  • M. Šlouf Ústav makromolekulární chemie AV ČR, v.v.i., Praha
  • T. Vacková Ústav makromolekulární chemie AV ČR, v.v.i., Praha
  • M. Nevoralová Ústav makromolekulární chemie AV ČR, v.v.i., Praha
  • J. Mikešová Ústav makromolekulární chemie AV ČR, v.v.i., Praha
  • J. Dybal Ústav makromolekulární chemie AV ČR, v.v.i., Praha
  • J. Pilař Ústav makromolekulární chemie AV ČR, v.v.i., Praha
  • A. Zhigunov Ústav makromolekulární chemie AV ČR, v.v.i., Praha
  • J. Kotek Ústav makromolekulární chemie AV ČR, v.v.i., Praha
  • J. Kredatusová Ústav makromolekulární chemie AV ČR, v.v.i., Praha
  • P. Fulín 1. Ortopedická klinika 1. LF UK a FN Motol, Praha
Klíčová slova: ultravysokomolekulární polyethylen, kloubní náhrady, otěr, oxidace

Abstrakt

Ultrahigh molecular weight polyethylene (UHMWPE) is a key component of modern total joint replacements (TJR). The most frequently replaced human joints are hips and knees, followed by shoulders, elbows, etc. However, UHMWPE liners are the most loaded components of the implants. Consequently, the main material-related reasons of TJR failures are wear and oxidative degradation of the polymer. Resistance to wear (i.e. release of microscopic particles from the polymer surface) is increased by radiation-induced crosslinking. Oxidation stability (i.e. resistance of polymer to chain scissions and deterioration of mechanical properties) is enhanced by means of suitable thermal treatment and sterilization protocols. The most recent trend is to employ a biocompatible stabilizer – vitamin E – for further improvement and fine-tuning of UHMWPE performance. This review summari­zes the recent developments in UHMWPE modifications, which come both from the author's institute and from the world, and which should further increase lifespan of total joint replacements.

Publikované
2013-10-15
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