Štúdium micelizácie 1-metoxy-3-(4-metylpiperazín-1-yl)propán-2-yl-4-propyloxyfenyl-karbamátu vo vodnom prostredí

  • L. Stopková Katedra farmaceutickej chémie, Farmaceutická fakulta, Univerzita Komenského v Bratislave, Bratislava, Slovensko
  • A. Danišová Katedra farmaceutickej chémie, Farmaceutická fakulta, Univerzita Komenského v Bratislave, Bratislava, Slovensko
  • Z. Šuchtová Katedra farmaceutickej chémie, Farmaceutická fakulta, Univerzita Komenského v Bratislave, Bratislava, Slovensko
  • F. Andriamainty Katedra farmaceutickej chémie, Farmaceutická fakulta, Univerzita Komenského v Bratislave, Bratislava, Slovensko
Klíčová slova: lokálne anestetiká, estery kyseliny fenylkarbámovej, konduktometria, kritická micelová koncentrácia, termodynamika

Abstrakt

Specific conductivities of local anaesthetic 1-methoxy-3-(4-methylpiperazin-1-yl)propan-2-yl-4-propyl-oxyphenyl carbamate (LM9) in aqueous solution were measured as a function of the concentration and temperature. The critical micelle concentration, CMC, degree of ionization and the counterion binding of the micelle were estimated from the dependence of the specific conductivity measurements at various temperatures. The dependence of CMC on temperature was shown to be U-shaped with a minimum at the temperature T = 298.15 K. Thermodynamic parameters (Gibbs energy ΔG°, enthalpy ΔH°, entropy ΔS°) for the micelle system were estimated by applying the mass action model. Molecule LM9 exhibited the enthalpy-entropy compensation phenomenon. The compensation temperature Tc of the studied compound was 301.79 K.

Publikované
2019-03-15
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