Glukánové častice ako nosiče biologicky aktívnych látok

  • Z. Plavcová Ústav molekulární biológie a farmaceutické biotechnologie, Farmaceutická fakulta, Veterinární a farmaceutická univerzita Brno, Brno
  • D. Rotrekl Ústav molekulární biológie a farmaceutické biotechnologie, Farmaceutická fakulta, Veterinární a farmaceutická univerzita Brno, Brno
  • J. Hošek Ústav molekulární biológie a farmaceutické biotechnologie, Farmaceutická fakulta, Veterinární a farmaceutická univerzita Brno, Brno
Klíčová slova: β-glukán, glukánové častice, očkovanie, nosič

Abstrakt

Nowadays, there is a continuous need to find new types of the safe drugs. This review deals with various possibilities of application of glucan particles (GP), and emphasizes their advantages when used as carrier for oral vaccination. The trend in research is to develop and improve methods of oral vaccination, where the antigen can produce the required immunological responses. Currently, only few vaccines are approved for oral administration. Glucan particles can be used for the stimulation of both humoral and cellular immune response. Substances encapsulated into GP are protected against the harsh environment of the gastrointestinal tract. The particles can be used as a carrier of siRNA and also as a carrier of various kinds of substances like resveratrol.

Publikované
2019-01-15
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Články