Antioxidative Activity of Potential Antihypertensives with Dual Effect
Abstrakt
The antioxidative properties of four 1-(2-benzofuran-2-yl-2-hydroxyethyl)-4-phenylpiperazines were studied by indirect spectrophotometric and direct ESR spin-trap methods. The radical scavenging activity of the tested compounds was determined. The compounds exhibit interesting structure-specific redox properties. Scavenging of DPPH radicals gave very poor results. The studied compounds did not affect the elimination of superoxide anion radicals; however, they caused stimulation of radical production. The hydroxyl radicals, however, were scavenged only by 2-fluoro¬phenyl derivatives, whereas the 4-fluorophenyl derivatives exhibited a slightly prooxidative effect. The capture of HO• radicals by 2-fluorophenyl derivatives was, according to the results of NMR analyses, attributed to the interaction with non-protonated piperazine nitrogen atom, which is stabilized by the hydrogen bond between the hydroxy group and fluorine atom.Stahování
Publikováno
15.02.2007
Jak citovat
Šeršeň, F., Loss, D., Csöllei, J., Popa, I., Vančo, J., & Gregáň, F. (2007). Antioxidative Activity of Potential Antihypertensives with Dual Effect. Chemické Listy, 101(1). Získáno z http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/1864
Číslo
Sekce
Články