Antioxidative Activity of Potential Antihypertensives with Dual Effect

Authors

  • F. Šeršeň Institute of Chemistry, Slovak Academy of Sciences, Bratislava,
  • D. Loss Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic,
  • J. Csöllei Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic,
  • I. Popa Laboratory of Growth Regulators, Palacky University, Olomouc, Czech Republic,
  • J. Vančo Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic,
  • F. Gregáň Department of Chemistry, Faculty of Natural Sciences, Matej Bel University, Banská Bystrica, Slovak Republic

Abstract

The antioxidative properties of four 1-(2-benzofuran-2-yl-2-hydroxyethyl)-4-phenylpiperazines were studied by indirect spectrophotometric and direct ESR spin-trap methods. The radical scavenging activity of the tested compounds was determined. The compounds exhibit interesting structure-specific redox properties. Scavenging of DPPH radicals gave very poor results. The studied compounds did not affect the elimination of superoxide anion radicals; however, they caused stimulation of radical production. The hydroxyl radicals, however, were scavenged only by 2-fluoro¬phenyl derivatives, whereas the 4-fluorophenyl derivatives exhibited a slightly prooxidative effect. The capture of HO radicals by 2-fluorophenyl derivatives was, according to the results of NMR analyses, attributed to the interaction with non-protonated piperazine nitrogen atom, which is stabilized by the hydrogen bond between the hydroxy group and fluorine atom.

Published

2007-02-15

How to Cite

Šeršeň, F., Loss, D., Csöllei, J., Popa, I., Vančo, J., & Gregáň, F. (2007). Antioxidative Activity of Potential Antihypertensives with Dual Effect. Chemické Listy, 101(1). Retrieved from http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/1864

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