Asymetrická Henryho reakce katalyzovaná měďnatými komplexy substituovaných imidazolidin-4-onů

  • P. Drabina Ústav organické chemie a technologie, Fakulta chemicko-technologická, Univerzita Pardubice, Pardubice
  • J. Hanusek Ústav organické chemie a technologie, Fakulta chemicko-technologická, Univerzita Pardubice, Pardubice
  • M. Sedlák Ústav organické chemie a technologie, Fakulta chemicko-technologická, Univerzita Pardubice, Pardubice
Klíčová slova: Henryho reakce, enantioselektivní katalýza, měďnaté komplexy, recyklovatelné katalyzátory

Abstrakt

This review summarizes recently published results of research on the enantioselective catalysts based on copper(II) complexes of substituted 4,5-dihydro-1H-imidazol-5-one and imidazolidine-4-one derivatives and their application in asymmetric Henry reaction. The enantioselectivity of 4,5-dihydro-1H-imidazol-5-one derivatives was generally low, nonetheless the transformation of the original 4,5-dihydro-1H-imidazol-5-one into the imidazolidine-4-one ring led to a fundamental enhancement of enantioselectivity (19 % ee to 92 % ee). The most efficient homogeneous catalysts based on imidazolidine-4-one derivatives were anchored to three different supports: a block copolymer; a swelling pearl-like polymer and magnetic nanoparticles. The influence of the type of the immobilization on the chemical yields and the enantioselectivity of Henry reaction was compared and discussed. Immobilized catalysts were reused and their catalytic efficiency after several cycles of application was studied.

Publikované
2016-09-15
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