Současný stav vývoje katalyzátorů pro anti-Markovnikovské hydratace terminálních alkynů

  • M. Kindl Ústav organické technologie, Vysoká škola chemicko-technologická v Praze, Praha
  • P. Kačer Ústav organické technologie, Vysoká škola chemicko-technologická v Praze, Praha
Klíčová slova: ruthenium, katalýza, hydratace alkynů

Abstrakt

CC triple bonds give the possibility to synthesize a plethora of chemical products by reacting with compounds containing electrophilic and nucleophilic moieties. Thus, an alkyne represents a valuable starting point in organic synthesis since the product very often remains unsaturated and one can further benefit from this in subsequent synthetic steps. Alkyne hydration, which is a simple, yet powerful, transformative tool, belongs to this astonishing variety of reactions. Anti-Markovnikov hydration is readily realized using special ruthenium catalysts; their review is presented in this paper, accompanied by their reaction mechanism and possible applications in pharmaceutical industry.

Publikované
2016-10-15
Sekce
Články