Degradation Products and Impurities of Paracetamol from Viewpoint of Analytical Detection

Page: 647

L. Hanyšová, P. Kastner, and J. Klimeš

Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Hradec Králové


A review on impurities and basic degradation products of paracetamol and their evaluation is presented. A wide variety of separation and non-separation methods are available for the purpose, such as derivatisation colorimetric, HPLC and FIA methods. The methods are compared with those used in pharmacopoeias.


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