Alternative in silico Methods for Toxicity Testing of Chemical Compounds

Page: 675

M. Tichýa, Z. Rotha, K. Bláhab, and A. P. Worth

National Health Institute, Šrobárova 48, 100 42 Praha 10, b Section of Environmental Hazards, Ministry of Environment, Praha, cEuropean Centre for Validation of Alternative Methods, Joint Research Centre, European Commission, 21020 Ispra, Italy


The aim of this contribution is to review trends, demands, criteria, possibilities and limitations in the identification of hazard associated with chemical compounds and chemical preparations and to outline the legislation and alternative methods in testing toxicity of chemicals, in particular QSAR methods and models and their use for regulatory purposes.


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