Study of Stability of 4-Aminophenol as Dominant Decomposition Product of Paracetamol

Page: 152

L. Hanysova, P. Kastner, and J. Klimes

Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Hradec Kralove


An HPLC method for determination of very low concentrations of 4-aminophenol was elaborated, and the kinetics of its decomposition at low temperatures and at laboratory temperature in the absence of light or under irradiation at 254 nm were compared. To increase the sensitivity of the method, derivatization of 4-aminophenol with various reagents was tested. Phthalaldehyde proved to be the best; its reaction at laboratory temperature in the presence of 2-sulfanylethanol is very fast. The derivatization conditions were optimized.


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