Activation of G-Proteins by Metabotropic Glutamate Receptors and GABAB Receptors
Department of Molecular Pharmacology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague
This review summarizes new findings on family 3 G-protein coupled receptors, also called metabotropic glutamate receptor (MGR) family, with respect to G-protein activation. In our studies we try to map the interface, which is crucial for G-protein activation. The interface includes intracellular loops of MGR, the loops 2 and 3 being especially important. On the GABAB receptor, the GB2 subunit contains enough molecular determinants for G-protein activation. Similarly to MGR, also here the corresponding intracellular loops are involved. On the G-protein side, the N-terminal preB1 region, C-terminal L9 loop and the extreme C-terminus are likely to contact the receptors in their active state.
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