Vibrational Circular Dichroism Spectroscopy as a Novel Tool for Structure Analysis

Page: 301

M. Urbanovaa, V. Setnickab, and K. Volkab

aDepartment of Physics and Measurements, Institute of Chemical Technology, Prague, bDepartment of Analytical Chemistry, Institute of Chemical Technology, Prague


Vibrational circular dichroism spectroscopy is briefly characterized and its application to stereochemical analysis is described. As examples, determination of absolute configuration of a pharmaceutically interesting precursor of femoxetine, monitoring of conformational changes of the peptide part of porphyrin-polypeptide complexes and of the sol-gel phase-transition process in tetrabrucine-porphyrin system are given.


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