Synthesis and Biological Activity of 2- and 6-C-Substituted Purine Bases, Nucleosides and Acyclic Nucleotide Analogues (Bader Award Lecture)

Page: 978

M. Hocek

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague


An overview of the author's recent achievements in the synthesis 2- and 6-C-substituted purines. Diverse approaches consisting mainly in heterocyclization, nucleophilic substitution and cross-coupling reactions were applied to the preparation of the title purines which were further transformed to target nucleosides and nucleotide analogues. Biological activity of the analogues is discussed.


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