Determination of Nanomolar Concentrations of Anthracyclines by Capillary Electrophoresis with UV Detection

Page: 1010

A. Gavendaa, J. Sevcika, b and J. Psotovac

aDepartment of Analytical Chemistry, Faculty of Science, Palacky University, bCenter of Analytical Chemistry of Molecular Structures, Faculty of Medicine, Palacky University, , cInstitute of Medical Chemistry, Faculty of Medicine, Palacky University, Olomouc


On-line preconcentration was used to get better UV detection limits in capillary electrophoresis. The sweeping effect in micellar electrokinetic chromatography was used to detect trace amounts of the biologically active group of anthracyclines in model samples. The improved sweeping preconcentration technique provides for excellent detection limits decreasing down to concentration 10-9 mol.l-1.


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