Determination of Antiarrhythmics and Their Metabolites in Clinical Samples Using a SPE-HPLC Combination

Page: 249

E. Brandsteterova and A. Ferencova

Department of Analytical Chemistry, Faculty of Chemical Technology, Slovak Technical University, Bratislava, Slovak Republic


An effective and simple SPE-HPLC assay for monitoring of clinically applied antiarrhythmics and their metabolites in serum samples was developed. In particular, the generally used SPE step has been modified for the clean-up and preconcentration procedure of clinical samples. Extraction recoveries for all analyzed compounds were in the range 81.4-90.7% for the concentration level m of serum.


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