Optimization of Following the Lead Content in Metabolism after Intoxication
aChimique of Professional Diseases, 1st Faculty of Medicine, Laboratory of Toxicology, bJ.Heyrovsky Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Prague
In the present medical practice a poisoning by lead is usually proved by measuring the concentration of Pb (II) ions in blood and urine and by the determination of d-aminolevulic acid (ALA) as well as by a semiquantitative determination of the porphyrines content in urine. The above analytical procedures are time-consuming and relatively expensive. The present communication describes the procedures used for obtaining independent analytical results in following the detoxication of the organism after a lead poisoning. It has been found that the quantity of Pb(II) ions determined in urine and blood and that of d-aminolevulic acid and of porphyrines in urine are not independent. A correlation was e.g. found between the porphyrine and the d-aminolevulic acid content. Thus the determination of one of last-mentioned substances is superfluous. The correlation analysis made it possible to propose a simplification and an acceleration of following the detoxication process in a patient.
Full text (PDF)