HPLC Determination of Paracetamol in Human Serum

Page: 373

D. Prochazkova*, P. Drasar** and J. Vacha*

*Institute of Clinical and Experimental Medicine, Prague, **Institute of Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague


A simple method was developed for measuring tha paracetamol concentration in human serum by reversed-phase HPLC. The suggested method is sufficiently precise, sensitive, and selective. The time of proper analysis does not exceed 15 min. The linear response of the detector has been proved for the range of 1-80 mg.l-1 paracetamol.


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