Voltammetric Determination of Antidepressant Imipramine in Pharmaceutical Preparations Using Boron-Doped Diamond Electrode
aInstitute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, b Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, c Institute of Electronics and Photonics, Faculty of Electrical Engineering and Information Technology, Slovak University of Technology in Bratislava, Slovak Republic
Keywords: imipramine, boron-doped diamond electrode, differential pulse voltammetry, detection limit
Herein, the direct electroanalytical determination of antidepressant imipramine using a boron-doped diamond electrode is presented. Cyclic and linear sweep voltammetric measurements revealed one distinct, irreversible and diffusion-controlled oxidation peak at +0.75 V (vs. Ag/AgCl) and oval-shaped peaks at +1.0 V and +1.5 V in the presence of Britton-Robinson buffer at pH 9. Using differential pulse voltammetry, the peak current of IMIP was found to be linear function of the concentration from 1.5 to 19.4 µM with the obtained detection limit of 0.5 µM and good repeatability (relative standard deviation of 5.4 % for n = 20 at 1.5 µM IMIP). The practical usefulness of the developed method was successfully manifested on the analysis of pharmaceutical tablets with significant recoveries (99.0100.4 %). Finally, boron-doped diamond electrode could be considered as an alternative to widely used chemically modified electrodes in antidepressant sensing and may be applied as a sensitive electrochemical sensor in routine pharmaceutical analysis.
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