Quaternary Ammonium Salts – Synthesis and Use

Page: 197

T. Padrtová, P. Marvanová, and P. Mokrý

Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno

Keywords: quaternary ammonium salts, Menshutkin reaction, tertiary amines, alkylation, antimicrobial effect, bacterial resistance


Quaternary ammonium salts (QUATs) are compounds with wide use in organic synthesis, pharmacy or other fields of industry. Thanks to their specific physical and chemical properties resulting from their amphiphilic character they are already used as phase-transfer catalysts, ionic liquids, dyes, antimicrobial agents and disinfectants, antiarrhythmics, bronchodilators etc. There is still an effort to prepare new active compounds. Several organosynthetic methods are used to prepare QUATs: probably the best way is the Menshutkin reaction. Recently, also a microwave synthesis was introduced to prepare QUATs bringing better yields, shorter reaction times and a possibility of solvent-free reactions.


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