Trinder Reaction in Clinical Biochemistry – Benefits and Limits

Page: 186

O. Wiewiorkaa,b,c, M. Dastycha,b, and Z. Čermákováa,b

a Department of Clinical Biochemistry, University Hospital Brno, b Department of Laboratory Methods, Faculty of Medicine, Masaryk University, Brno, c Department of Biochemistry, Faculty of Medicine, Masaryk University, Brno

Keywords: clinical biochemistry, Trinder reaction, diagnostic tests, interference


This article reviews the Trinder chromogenic reaction and describes its discovery, further development, current state and use in practice. It has been known for nearly half a century as a universal and analytically specific chromogenic method that is abundantly used in clinical biochemistry tests. The article provides information on the benefits and shortcomings of the Trinder reaction in comparison to alternative methods. It also reviews substances interfering in this reaction. This may be particularly helpful for a biochemical analyst or a physician in determination the cause of discrepant laboratory results, and thus pr


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