Pharmacophore Modelling Used in Rational Drug Design

Page: 575

P. Koščová and I. Provazník

Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication, Brno University of Technology

Keywords: drug discovery, rational drug design, pharmacophore


Development of information technologies in recent decades has facilitated also a great progress in the development of new drugs. Methods of Computer-Aided Drug Design allow us to explore the spatial interaction between the receptor and a potential drug. The review deals with a brief summary of these computational methods and is mainly focused on pharmacophore modelling, one of the modern approaches in drug design that has proved to be a useful tool.


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