Orodispersible Films, Technologies of Their Manufacturing and Specific Excipients

Page: 424

V. Walicová, J. Gajdziok, and D. Vetchý

Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno

Keywords: orodispersible films, solvent-casting method, hot-melt extrusion, film forming polymers, plasticizers, sweeteners, flavoring agents, saliva-stimulating agents


Orodispersible films represent a modern fast dissolving dosage form. They are commonly referred to as a thin flexible film that readily dissolves or disperses in the oral cavity. To apply this innovative drug delivery system, no water or swallowing is needed. Furthermore, they provide a rapid onset of action and can enhance compliance of specific patient groups (especially paediatric and geriatric). Manufacturing the orodispersible films is a flexible process. At present, solvent-casting technique and hot-melt extrusion are methods of choice. Main constitutive excipients are film-forming polymers. Other basic excipients are plasticizers and, in many cases, taste and smell masking substances. Orodispersible films are nowadays available on the market and, in the future, they will undoubtedly compete with orodispersible tablets.


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