Separation of Enantiomers of Cathinones by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors

Page: 200

M. Hegrová, K. Řezanková, M. Kuchař, and P. Řezanka

University of Chemistry and Technology, Prague, Czech Republic

Keywords: cyclodextrin, chiral separation, capillary electrophoresis, cathinon

 

This paper deals with a chiral separation of six cathinones using three commercially available cyclodextrins as additives to the background electrolyte consisting of a phosphate buffer at pH 2.5. The best resolution values were obtained by the addition of sulfated ?-cyclodextrin at 5 mmol L–1 concentration in the background electrolyte. Four complete chiral separations of racemic cathinones were achieved. Other two racemic cathinones were successfully enantioseparated by addition of carboxymethyl¬ated ?-cyclodextrin at 15 mmol L–1 concentration in the background electrolyte. For one of the cathinones analyzed, the apparent stability constants of ?-cyclodextrin and the average apparent stability constants of carboxy-methylated ?-cyclodextrin were calculated and it was found that a more stable complex is formed for carboxy-methylated ?-cyclodextrin.

 

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