Microreactors and Microfluidic Reactors for Synthesis of Fine Chemicals

Page: 892

P. Klusoň a,b, P. Stavárek a, S. Hejda a, V. Pěnkavová a, M. Bendová a, and H. Vychodilová a

aInstitute of Chemical Process Fundamentals, Academy of Sciences of the Czech Republic; bInstitute for Environmental Studies, Faculty of Science, Charles University

Keywords: microfluidic reactor, special chemicals, stereoselective hydrogenation, pressure loss, (R)-Ru-BINAP complex, viscosity of ionic liquids


The primary intention of this work was to bring information on the research, development, and construction of advanced microreactor platforms for the syntheses of fine chemicals. A brief overview was provided on the systems used for practical gas and liquid phase reactions, homogeneous and heterogeneous catalytic reactions, polymerizations, and also for reactions with involvement of light. Then an attention was paid to the tubular continuous microreactors, especially to those which are usually referred to as microfluidic chips. In the past, these microfluidic reactors have been used for various organic reactions in the field of fine chemistry. Finally, an algorithm has been described for a validation of the microfluidic reactor platform for flow conditions of specific solvents mixtures used in stereoselective hydrogenation of ß-ketoesters with chiral metal complexes, and in the presence of specific ionic liquids.


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