Hyphenation of Electro¬chemical Methods with Mass Spectrometry The Potential for Analytical and Physical Chemistry and Biochemistry
a Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Prague, b Department of Physiology and Biochemistry, Faculty of Physical Education and Sport, Charles University in Prague, Prague, c Department of Agro-Environmental Chemistry and Plant Nutrition, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Prague
Keywords: hyphenation, electrochemistry, mass spectrometry, mimetics
The contribution provides a critical overview about hyphenation of electrochemical methods (EC) with mass spectrometry (MS). It is focused on the difficulties of the electrochemical cell construction, selection of the electrodes and electrodes arrangements. Three possible applications of on-line EC/MS are introduced and discussed: (i) electrochemical activation of nonpolar chemicals, (ii) separation of chemicals using electrochemically generated nascent ions and (iii) studies of mechanisms of electrochemical reactions including the mimicking of the detoxification process provided using cytochrome P450.
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