Chiral Selector as a Tool for Determination of Enantiomeric Ratio in Mixture by Molecular Spectroscopy with Multivariate Calibration
Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava
Keywords: chirality, molecular spectrometry, multivariate calibration, chiral selectors, enantiomeric mixture
This review provides brief information on using the chiral selector in a new approach to chiral analysis, that is, a combination of molecular spectroscopy with multivariate calibration. This new approach provides a more rapid, more sensitive and cheaper chiral analysis of many compounds, as compared to the traditional chiral methods. The interaction between the chiral selector and the enantiomers forms a diastereomeric complex, which causes the occurrence of the spectral shifts. These shifts are small and they must be evaluated by multivariate calibration.
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