Hot-stage Microscopy in Pharmaceutical Industry

Page: 687

M. Šimeka,b and B. Kratochvíla

aDepartment of Solid State Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology, Prague, bZentiva, k.s., Prague

Keywords: hot-stage microscopy, API, drug, analysis, pharmacy


Hot-stage microscopy (HSM) affords combined light microscopy and thermal analysis, enabling the study of materials as a function of temperature and time. This combination involves visual examination and gives valuable information on the compound regarding its melting point, phase transformation, new phase formation, solid-state interactions, particle and solid dispersions analysis during heating. HSM gives a unique opportunity to visually follow thermal changes. Model cases of HSM application show its current usage in pharmaceutical industry thus supporting and inspiring its research.


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