Magnetoferritin and Its Potential Bioapplications

Page: 673

L. Melnikovaa, I. Šafaříkb,c, K. Pospíškovác, M. Koralewskid, Z. Mitróováa, and P. Kopčanskýa

a Institute of Experimental Physics, Slovak Academy of Sciences, Košice, Slovakia, b Department of Nanobiotechnology, Institute of Nanobiology and Structural Biology of Global Change Research Centre, České Budějovice, Czech Republic, c Regional Centre of Advanced Technologies and Materials, Palacký University, Olomouc, Czech Republic, d Faculty of Physics, Adam Mickiewicz University, Poznań, Poland

Keywords: magnetoferritin, apoferritin, magnetite, magneto-optical properties, peroxidase activity, bioapplication


Magnetoferritin is a metalloprotein composed of a protein coat (apoferritin) surrounding the magnetic iron oxide nanoparticles. Physicochemical characterization of magnetic, structural and morphological properties, size distribution and stability of magnetoferritin have been extensively investigated. Magneto-optical properties of magnetic nanoparticles in magnetoferritin can be applied in in vivo diagnosis of various diseases associated with the formation of magnetite in pathological processes in tissues. In addition, the confirmed peroxidase activity enables magnetoferritin to be used in important bioapplications.


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