Electrochemical Determination of Amlodipine in Pharmaceutical Formulations and in Human Urine Using a Boron-Doped Diamond Electrode

Page: 463

K. Cinková and Ľ. Švorc

Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava

Keywords: amlodipine, boron-doped diamond electrode, differential pulse voltammetry, detection limit


The boron-doped diamond electrode (BDDE) as a perspective electrochemical sensor in association with differential pulse voltammetry was used for a sensitive determination of Amlodipine (AML) was determined in pharmaceutical formulations and in urine using a BDDE. AML undergoes an irreversible electrochemical oxidation with a peak potential of ca. +0,75 V (vs. Ag/AgCl, 3 mol l–1 KCl in a mixture of Britton-Robinson buffer of pH 5 and methanol, 10:1). The obtained parameters were as follows: the linear concentration range at 2·10–7 – 6·10–6 mol l–1 and at 6·10–6 – 3.8·10–5 mol l–1, detection limit 7.4·10–8 mol l–1 and relative standard deviation 3.6 % at 9.9·10–6 mol l–1 AML, n = 20). The proposed procedure was used in the analysis of commercial tablets and model urine samples with good recoveries. The method is simple, rapid, sensitive and of good repeatability.


Full text (PDF)