The Influence of Persistent Organic Pollutants on Mitochondrial Functions and origin of Metabolic Syndrome

Page: 418

J. Dvořákováa, M. Kripnerováb, M. Čedíkovác,d, V. Babuškae, V. Kuldae, M. Peštab,d, M. Králíčkovác,d, and D. Müllerováa

Department of Public Health and Preventive Medicine, b Institute of Biology, c Department of Histology and Embryology, d Biomedical Centre, e Institute of Medical Chemistry and Biochemistry, Faculty of Medicine in Pilsen, Charles University in Prague

Keywords: persistent organic pollutants, mitochondria, diabetes mellitus, obesity, metabolic syndrome

 

Persistent organic pollutants are bioaccumulative and toxic to living organisms. Persistent substances may increase oxidative stress and start inflammatory processes, which are the major factors in the pathogenesis of obesity-related diseases. A clear link was found between mitochondrial dysfunction and the type 2 diabetes mellitus. A mutation in mitochondrial DNA ß-cells of pancreas leads to the worsening of insulin secretion, cell apoptosis and subsequent reduction of ß-cells.

 

Full text (PDF)