RAS Proteins – Key Re¬gulators of Cell Cycle

Page: 364

H. Gbelcováa,b, S. Rimpelováa, Z. Knejzlíka, V. Repiskáb, T. Rumla, and D. Böhmerb

a Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, b Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava

Keywords: RAS, activating mutation, farnesylation, cancer, RASopathy


RAS proteins are small guanosine triphosphatases controlling the cell growth, differentiation, proliferation, survival, and death. They are encoded by ras proto-oncogenes, frequently mutated, in many cancer tissues and in the whole group of congenital defects. Understanding the structure, kinetics and signaling of RAS proteins allow the use of ras genes and RAS proteins as diagnostic bio¬markers.


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