Pulsatile Drug Delivery Systems

Page: 353

D. Sabadkováa, A. Franca, J. Muselíka, D. Neumannb, and D. Vetchýa

a Department of Pharmaceutics, University of Veterinary and Pharmaceutical Sciences, Brno, b Department of Pediatrics, University Hospital, Hradec Králové

Keywords: drug delivery systems, pulsatile release, delayed release, circadian rhythm


This review is focused on the basic principles of the delivery systems with a pulsatile release pattern. Such systems are designed according to the circadian rhythm of the body. Time-controlled, stimuli-induced and externally regulated pulsatile drug delivery systems are recognized. The drug release of time-controlled systems occurs after a predefined time lag. Stimuli-induced systems release the drug as a reaction to changeable conditions in the body (pH, glucose level). The drug release of externally regula¬ted systems is controlled via external stimulus (magnetism, ultrasound). Pulsatile drug delivery systems rank among modern dosage forms which provide many therapeutic benefits.


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